Karen Yee Selected Research

Decitabine

12/2023	Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study.
11/2023	Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine.
1/2020	Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study.

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Karen Yee Research Topics

Disease

20	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2024 - 01/2008
10	Neoplasms (Cancer) 01/2023 - 04/2008
8	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2024 - 04/2011
7	Leukemia 02/2016 - 11/2005
5	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 12/2008
2	Neutropenia 04/2024 - 12/2023
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2023 - 02/2013
2	Opioid-Related Disorders (Opiate Addiction) 01/2023 - 11/2020
2	Venous Thromboembolism 01/2023 - 12/2020
2	Kidney Diseases (Kidney Disease) 01/2021 - 01/2021
2	Primary Myelofibrosis (Myelosclerosis) 09/2017 - 11/2015
1	Pneumonia (Pneumonitis) 12/2023
1	Febrile Neutropenia 12/2023
1	Tumor Lysis Syndrome 03/2023
1	Nausea 03/2023
1	Hypertriglyceridemia 02/2023
1	Thrombosis (Thrombus) 12/2020
1	Venous Thrombosis (Deep-Vein Thrombosis) 12/2020
1	Pulmonary Embolism 12/2020
1	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 01/2020
1	Chromosome Aberrations (Chromosome Abnormalities) 10/2018
1	Nephrotic Syndrome (Syndrome, Nephrotic) 07/2018
1	Fatigue 04/2016
1	Insulin Resistance 12/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2014
1	Philadelphia Chromosome 02/2013

Drug/Important Bio-Agent (IBA)

8	Cytarabine (Cytosar-U)FDA LinkGeneric 04/2024 - 11/2005
4	guadecitabineIBA 04/2024 - 09/2015
3	Decitabine FDA Link 12/2023 - 01/2020
3	Glutens (Glutelin)IBA 01/2021 - 07/2018
2	Azacitidine (5 Azacytidine)FDA Link 12/2023 - 04/2011
2	BilirubinIBA 03/2023 - 04/2016
2	pegaspargase (Oncaspar)FDA Link 02/2023 - 01/2023
2	Naloxone Drug Combination Buprenorphine FDA Link 01/2023 - 11/2020
2	Asparaginase (Elspar)FDA Link 01/2023 - 12/2020
2	Mitoxantrone (Novantrone)FDA LinkGeneric 10/2021 - 01/2008
2	RG7388IBA 01/2021 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2008
1	Hemoglobins (Hemoglobin)IBA 01/2024
1	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 11/2023
1	HhAntag691IBA 11/2023
1	EnzymesIBA 11/2023
1	Ribavirin (Virazole)FDA LinkGeneric 11/2023
1	Peptide Initiation Factors (Initiation Factor)IBA 11/2023
1	olutasidenibIBA 07/2023
1	RNA Splicing FactorsIBA 06/2023
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 06/2023
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 03/2023
1	Alanine Transaminase (SGPT)IBA 03/2023
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 05/2022
1	GSK2879552IBA 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Biomarkers (Surrogate Marker)IBA 10/2021
1	alvocidib (flavopiridol)IBA 10/2021
1	Immunoconjugates (Immunoconjugate)IBA 01/2021
1	Core Binding Factors (Core-Binding Factor)IBA 01/2021
1	DCLL9718SIBA 01/2021
1	C-Type Lectins (C-Type Lectin)IBA 01/2021
1	RO6839921IBA 10/2020
1	cedazuridineIBA 01/2020
1	AlbuminsIBA 10/2018
1	Hormones (Hormone)IBA 01/2018
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2018
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2017
1	selinexorIBA 01/2017
1	Exportin 1 ProteinIBA 01/2017
1	OTX015IBA 04/2016
1	RG7112IBA 02/2016
1	Proto-Oncogene Proteins c-mdm2IBA 01/2016
1	acivicin (AT 125)IBA 09/2015
1	LipidsIBA 12/2014
1	LDL CholesterolIBA 12/2014
1	LDL Lipoproteins (beta Lipoproteins)IBA 12/2014
1	HDL CholesterolIBA 12/2014
1	HDL LipoproteinsIBA 12/2014
1	Triglycerides (Triacylglycerol)IBA 12/2014
1	Insulin (Novolin)FDA Link 12/2014
1	Glucose (Dextrose)FDA LinkGeneric 12/2014
1	Dietary Carbohydrates (Carbohydrate, Dietary)IBA 12/2014
1	CarbohydratesIBA 12/2014
1	tosedostatIBA 04/2013
1	Liposomes (Liposome)IBA 02/2013
1	Vincristine (Oncovin)FDA LinkGeneric 02/2013
1	MetalsIBA 10/2012
1	Clioquinol (Vioform)FDA Link 10/2012
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2012
1	IonophoresIBA 10/2012
1	linifanibIBA 08/2012

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2008
8	Drug Therapy (Chemotherapy) 04/2024 - 01/2008
3	Induction Chemotherapy 12/2023 - 01/2008
2	Erythrocyte Transfusion 01/2024 - 11/2015
2	Hematopoietic Stem Cell Transplantation 06/2023 - 01/2021
2	Aftercare (After-Treatment) 01/2023 - 04/2008
1	Ambulatory Care (Outpatient Care) 01/2023
1	DFCI 91-01 protocol 01/2023
1	Catheters 12/2020
1	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 12/2014
1	Cell Transplantation 02/2013